Hormonal Genomics

£149.99

  • Home Test
  • DNA Saliva Sample

Hormonal genomics points you to your genetic risk factors and helps you mitigate them. Hormonal health is key to the balance of life. Areas of concern for women are general thyroid, PCOS and gestational diabetes. In men, low testosterone and infertility, have an essential genetic component. Understanding your genetic predispositions will aid in managing hormonal conditions.

Hormonal Genomics

Hormonal Genomics

Pitutiary Disorders

Acromegaly Learn More

What is Acromegaly
Acromegaly is a rare hormonal disorder that develops when the pituitary gland produces excess growth hormone during adulthood. Acromegaly usually affects middle-aged adults and in this condition, bones increase in size, including those of your hands, feet and face it could cause increased pressure on joints, thereby increasing the risk of developing osteoarthritis. In children with an active growth cycle, excess growth hormone levels can cause a condition called gigantism. Such children have exaggerated bone growth and an abnormal increase in height. Acromegaly could cause hypertension and increase the risk of developing diabetes.

Growth Hormone Deficiency Learn More

What is Growth Hormone Deficiency
Growth Hormone Deficiency (GHD) is a rare disorder characterized by the inadequate secretion of growth hormone (GH) from the anterior pituitary gland. GHD can be present from birth (congenital), resulting from genetic mutations or from structural defects in the brain it can also be acquired later in life as a result of trauma, infection, radiation therapy, or tumor growth within the brain.

Adrenal Disorders

Addison's Disease Learn More

What is Addison's Disease
Addison's Disease or Adrenal insufficiency is a pathological condition wherein the adrenal glands are unable to sufficiently produce adrenal hormones, mainly cortisol other hormones affected include aldosterone and testosterone. Cortisol is known to affect every organ and tissue in the body it plays a major role in maintaining blood pressure, cardiovascular function, immune system and inflammatory response. Addison's Disease can potentially be a life-threatening condition.

Primary Aldosteronism (Hyperaldosteronism) Learn More

What is Primary Aldosteronism (Hyperaldosteronism)
Primary Aldosteronism is a condition characterized by overproduction of the adrenal hormone 'aldosterone'. This in turn causes increase in sodium levels, causing hypertension and decrease in potassium levels, resulting in hypokalemia and impaired nerve and muscle function in the body. The main causes are benign tumor growth on the adrenal glands or overactivity of both adrenal glands. Hypertension can lead to further complications such as cardiovascular diseases and kidney diseases.

Pediatric Disorder

Pediatric Obesity Learn More

What is Pediatric Obesity
Pediatric or childhood obesity is a growing global epidemic that requires attention due to the burden on healthcare system for children and adults. Obesity is characterized by having a high fat composition and a BMI of 30 and above. It is a result of imbalance between energy intake and its expenditure. Hormones can play a role in increase or decrease of food intake, energy expenditure and other metabolic changes that may change body composition due to increase in fat, cholesterol, or glucose levels. Obesity increases the risk of other conditions such as cardiovascular diseases, diabetes, hypertension, stroke, breathing disorders and depression.

Congenital Hypothyroidism Learn More

What is Congenital Hypothyroidism
Congenital hypothyroidism is a partial or complete loss of function of the thyroid gland that affects infants from birth. It occurs when the thyroid gland fails to develop or function properly, resulting in lower than normal levels of thyroid hormones. Sometimes, the pituitary gland fails to send signals to produce thyroid hormones. If the condition is not diagnosed and treated in a timely manner, it can result in irreversible neurological problems and poor growth. Genetic causes account for about 15 to 20 percent of cases of congenital hypothyroidism.

Women's Health

Endometriosis (Women Only) Learn More

What is Endometriosis
The endometrium is a tissue lining the inner wall of the uterus. Endometriosis is a gynecological condition characterized by the presence and growth of endometrial tissue outside the uterus. Even outside the uterus, the endometrial tissue is functional and can thicken and bleed, mimicking normal tissue function. This condition can cause irritation and inflammation in other organs.

Leiomyoma (Women Only) Learn More

What is Leiomyoma
Leiomyoma, also known as uterine fibroid, is a common benign tumor of the uterus. Tumors can be numerous and large but typically remain benign. Hormones like estrogen and progesterone are believed to be the factors responsible for uterine fibroids, as they stimulate the growth of uterine lining. Leiomyomas are common in reproductive-aged women and may potentially cause infertility or pregnancy-related complications.

PCOS (Women Only) Learn More

What is PCOS
Polycystic Ovary Syndrome (PCOS) is a condition characterized by the formation of cysts in the ovaries and an irregularity or failure in ovulation which can cause irregular periods. It is one of the most common causes of female infertility. Although its exact cause is unknown, potential causes include excess production of androgens and hormonal imbalances of follicle stimulating hormone (FSH) and luteinizing hormone (LH).

Premature Ovarian Failure (Women Only) Learn More

What is Premature Ovarian Failure
Premature Ovarian Failure (POF), also known as early menopause, is characterized by the cessation of menses before the age of 40 years. It results from a rapid decrease or complete exhaustion of eggs from follicles in the ovaries and can cause fertility issues. Due to POF, the ovaries are unable to produce the required amounts of ovarian hormones like estrogen and progesterone. Hormonal imbalances can further cause hormone-related complications such as osteoporosis and heart diseases.

Men's Health

Erectile Dysfunction (Men Only) Learn More

What is Erectile Dysfunction
Erectile dysfunction (impotence) is the frequent or consistent inability to develop or sustain a penile erection that is satisfactory for engaging in sexual intercourse. While most men occasionally fail to get an erection or lose one prematurely during sexual activity, some men suffer from these problems regularly. Erectile dysfunction could cause hormonal imbalances such as low testosterone, high prolactin and abnormal thyroid hormone levels. Erectile dysfunction could also result in chronic liver or kidney conditions affecting blood vessels and nerves.

Low Testosterone (Men Only) Learn More

What is Low Testosterone
Testosterone is the male sex hormone produced by the testes and it is important for normal male sexual development and functions. In puberty, testosterone helps in the development of male features like body and facial hair, deeper voice and muscle strength testosterone is also required for sperm production. The condition in which there is low testosterone levels is called Testosterone Deficiency Syndrome (TD) or Low Testosterone (Low-T). Low testosterone levels can interfere with sexual function and moods. Older men tend to have low blood testosterone levels as levels generally decrease with age.

Male Infertility (Men Only) Learn More

What is Male Infertility
Male infertility is due to low sperm production, abnormal sperm function, or blockages that prevent the delivery of sperm, causing difficulty in or the loss of ability for conception. Sperm abnormality can be either due to an unusually short life span of the sperm and/or low mobility. Infertility may also result from a hormone deficiency.

Prostate Enlargement (Men Only) Learn More

What is Prostate Enlargement
Prostate enlargement or Benign Prostatic Hyperplasia (BPH) is a condition in which the prostate gland becomes enlarged and is not cancerous. The prostate goes through two main growth periods as a man ages first occurs early in puberty, when the prostate doubles in size and the second phase begins around the age of 25 and continues throughout most of a man's life. Enlargement often occurs with the second growth phase. Imbalance of testosterone levels can lead to prostate enlargement. As the prostate enlarges, the gland presses against the urethra, weakening the bladder and eventually, one may lose the ability to empty the bladder completely.

Gynecomastia (Men Only) Learn More

What is Gynecomastia
Gynecomastia is the most common breast condition in males it is characterized by generalized enlargement of the breast tissue with the presence of a rubbery or firm mass extending from the nipple. The most important cause of gynecomastia is an imbalance between the levels of estrogen and androgen. Other causes include conditions that interfere with testosterone levels in the body and hormonal changes which occur as a part of ageing. Gynecomastia can occur in the neonatal, pubertal and older ages.

Thyroid Related Disorders

Goiter Learn More

What is Goiter
Goiter is the abnormal enlargement of the thyroid gland. It is usually painless, however, a large Goiter cause difficulty in swallowing and breathing. Goiter can occur when the thyroid gland produces either excess thyroid hormone (hyperthyroidism), insufficient (hypothyroidism) levels of the thyroid hormone, or may occur even with a normal production of thyroid hormone. Goiter could be caused due to a lack of iodine in diets, consumption of a diet with Goiter-promoting foods, or when the pituitary gland stimulates thyroid growth. Goiter could affect the female population significantly more than the male population.

Graves' Disease Learn More

What is Graves' Disease
Graves' Disease (GD) is an autoimmune disorder causing hyperfunction of the thyroid gland, leading to thyroid enlargement and increased thyroid hormone production. There is an increase in the fraction of triiodothyronine hormone (T3) relative to thyroxine hormone (T4). Graves' disease is a common cause of hyperthyroidism. Women are at an increased risk of developing Graves' Disease.

Hashimoto's Thyroiditis Learn More

What is Hashimoto's Thyroiditis
Hashimoto's thyroiditis is an autoimmune disease of the thyroid gland. This leads to the development of hypothyroidism, though the disease may occur with a normal thyroid activity. Hashimoto's disease can be detected chemically by the presence of antibodies, rise in TSH level, or low blood levels of thyroid hormones.

Hypothyroidism Learn More

What is Hypothyroidism
Hypothyroidism is a condition resulting from the deficiency of thyroid hormones. Thyroid hormones play a major role in metabolism and have a direct effect on your body's temperature, heartbeat and metabolism. There are two types of hypothyroidism. Primary hypothyroidism is caused due to problems with the thyroid gland and secondary hypothyroidism occurs due to a failure in adequate thyroid-stimulating hormone (TSH) secretion from the pituitary gland or in the secretion of thyrotropin-releasing hormone (TRH) from the hypothalamus.

Diabetes

Gestational Diabetes Learn More

What is Gestational Diabetes
Gestational Diabetes Mellitus (GDM) is a condition wherein women without a previous diagnosis of diabetes exhibit abnormal blood glucose levels during pregnancy. During pregnancy, rise in placental hormones causes the body to become slightly resistant to insulin so that more sugar is available in the blood to be passed to the fetus. If insulin resistance increases, it causes abnormally high sugar levels in the bloodstream, resulting in gestational diabetes mellitus.

Type 1 Diabetes Learn More

What is Type 1 Diabetes
Type 1 Diabetes Mellitus is a chronic disease and a form of diabetes wherein the body produces little or no insulin. Contrastingly, in Type 2 Diabetes Mellitus, insulin is produced but the cells of the body become resistant to insulin or lose the ability of insulin responsiveness. Complications associated with Type 1 Diabetes Mellitus are cardiovascular diseases, nerve damage, kidney damage, eye damage, skin conditions and osteoporosis.

Osteoporosis and Bone Health Disorders

Osteoporosis in Postmenopausal (Women Only) Learn More

What is Osteoporosis in Postmenopausal women
Osteoporosis is a condition in which a low bone mass and altered microarchitecture of the bone leads to increased risk of fracture. At menopause the normal bone turnover cycle is impaired by estrogen deficiency. The amount of bone resorbed exceeds the amount deposited, which leads to a net loss of bone.

Osteoporosis Learn More

What is Osteoporosis
Osteoporosis is a condition in which a low bone mass and an altered microarchitecture of the bone leads to increased risk of fracture. Primary osteoporosis refers to osteoporotic conditions which are not related to other chronic illnesses and is usually associated with aging and decreased gonadal function such as decreased level of estrogen. In contrast, secondary osteoporosis is the type of osteoporosis caused by other health problems. Osteoporosis could be caused by hormonal imbalances of the parathyroid hormone, low levels of sex hormone, or imbalances in pituitary hormones. High concentrations of the thyroid hormone can lead to increased bone breakdown compared to bone formation, which affects bone density and causes osteoporosis.

Primary Hyperparathyroidism Learn More

What is Primary Hyperparathyroidism
Parathyroid glands are about the size of a grain of rice and are located in the neck; the glands produce the parathyroid hormone. Primary Hyperparathyroidism is a condition in which there is an excess production and release of the parathyroid hormone in the bloodstream due to overactivity of one or more of the body's four parathyroid glands. Parathyroid hormone maintains an appropriate balance of calcium in the bloodstream and in tissues that depend on calcium for proper functioning.

Description of Test

Genetic testing is a type of medical test that identifies changes in genes, chromosomes, or proteins. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder. It identifies how your genetic makeup influences the course of a disease and, conversely, how environment, lifestyle and drug treatments can trigger mutations that alter that course. By understanding these ever-changing variables, healthcare providers can make more informed choices in treatment, often preemptively. The availability of the human genomic sequence is changing the way in which biological questions are addressed.

Hormones are chemical messengers you produce to regulate different functions of your body. Having too much or too little of certain hormones (hormone imbalance) can impact your wellbeing.

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